Práticas adotadas para o descarte de resíduos de medicamentos e saneantes domissanitários por alunos da educação básica

The study objective was to obtain information on the practices adopted by the students of the High School of Course technical of Environmental Sanitation and Biotechnology of Cedup Renato Ramos da Silva School, in Lages, SC for the disposal of residues of medicines and household cleaners in their homes. This study was developed by students of scientific initiation of High School (PIBIC/EM). For data collection a semi-structured questionnaire was applied to the students of the respective courses during the period of their classes in the Institution. It was observed that 63% do not have knowledge about the correct procedure of disposal of drug residues and 55.6% still discard the expired drugs in the common trash. Regarding household cleaning products, 90.1% of the participants do not know how to dispose of these residues in their homes, despite frequent use (83.8%). Concerning residues of insecticides, rodenticides and repellents, about 50% of the participants discard the waste in the common bin and 44% do not know how to dispose of these products. Overall, this study showed that High School students from the Environmental Sanitation and Biotechnology technical Course inappropriately dispose of the drug residues and sanitary household products in their homes. Thus, it emphasizes the importance of including the topic about waste management in basic education courses.Este estudo teve como objetivo levantar informações sobre as práticas adotadas pelos alunos de Ensino Médio do Curso técnico em Saneamento Ambiental e Biotecnologia do Cedup Renato Ramos da Silva de Lages, SC para o descarte dos resíduos de medicamentos e saneantes domissanitários em suas residências. O estudo foi desenvolvido por estudantes de iniciação científica do Ensino Médio (PIBIC/EM). Para a coleta de dados foi aplicado um questionário semiestruturado aos alunos do respectivo curso durante o período de suas aulas na Instituição. Observou-se que 63% não têm conhecimento sobre o procedimento correto de descarte dos resíduos de medicamentos e 55,6% ainda fazem o descarte dos medicamentos vencidos em lixeira comum. Com relação aos produtos domissanitários, 90,1% dos participantes desconhecem a forma de descarte desses resíduos em suas residências, apesar do uso frequente (83,8%). Já quanto relação aos resíduos de inseticidas, raticidas e repelentes, cerca de 50% dos participantes descartam os resíduos na lixeira comum e 44% desconhecem a forma de descarte desses produtos. No geral, este estudo mostrou que os estudantes do Ensino Médio do Curso técnico em Saneamento Ambiental e Biotecnologia não descartam adequadamente os resíduos de medicamentos e saneantes domissanitários gerados em seu domicílio. Dessa forma, enfatiza-se a importância da inserção do tema sobre gestão de resíduos nos cursos de formação básica. &nbsp

Representações sociais dos sentimentos vivenciados pelo paciente portador de neoplasia

The aim was to identify the social representations about cancer of patients undergoing cancer treatment. This is an exploratory-descriptive study with a qualitative approach with data that used the research grounds following assumptions of the proposed Theory of Social Representations. The research had a total of 92 patients of various cancer diagnoses during chemotherapy treatment. Data were collected through individual interviews, using a semi-structured questionnaire where the patient had to enumerate the first 5 words that came to their mind from the most important to the least important. Among the words evoked, the ones that were repeated the most were fear, death and treatment, sadness and healing. Evidencing, therefore, the fear that the patient feels in the face of cancer. In the fifth line of words, the most evoked terms were healing, faith, God, hope. At the beginning of the treatment, the patient is afraid of a disease that still has an important psychosocial impact on his daily life. Oncological therapy performed with quality and efficiency, by qualified professionals who assist the patient in all its dimensions, who know parts of their feelings during treatment, can help to reduce suffering and reduce the physical and psychological impacts on the patient.Objetivou-se identificar as representações sociais sobre o câncer dos pacientes em tratamento oncológico. Trata-se de um estudo exploratório-descritivo com abordagem qualitativa com dados que utilizaram fundamentação da pesquisa seguindo pressupostos da Teoria das Representações Sociais proposta. A pesquisa teve o total de 92 pacientes de diversos diagnósticos de câncer durante o tratamento quimioterápico. Os dados foram coletados por meio de entrevistas individuais, utilizando um questionário semiestruturado onde o paciente precisou enumerar as 5 primeiras palavras que viessem a sua cabeça da de maior importância para a de menor importância. Entre as palavras evocadas as que mais se repetiram foram medo, morte e tratamento, tristeza e cura. Evidenciando, portanto, o temor que o paciente sente frente o câncer. Na quinta linha de palavras os termos mais evocados foram cura, fé, Deus, esperança. No início do tratamento, o paciente encontra-se temeroso diante de uma doença que ainda tem uma repercussão psicossocial importante no seu dia-a-dia. A terapêutica oncológica realizada com qualidade e eficiência, por profissionais qualificados que assistem o paciente em todas as suas dimensões que conhecem partes de seus sentimentos durante o tratamento, pode auxiliar na redução do sofrimento e diminuir os impactos físicos e psíquicos no paciente

The presence of depressive symptoms and cognitive performance among older individuals with and without self-reported chronic diseases

ABSTRACT. Dementias secondary to cardiovascular diseases are the second cause of neurogenerative diseases. These conditions can be prevented by controlling risk factors, and it is necessary to observe the relationship between chronic diseases. Objective: to know the influence of chronic non-communicable diseases on cognition and depressive symptoms in the elderly, amid the COVID-19 pandemic. Methods: 578 older adults were evaluated using a sociodemographic questionnaire, the Brazilian Telephone version of the Mini Mental State Examination (Braztel-MMSE), the Geriatric Depression Scale (GDS-15) and an open questionnaire related to NCDs. Results: the association of Non-Communicable Diseases (NCD) with age, depressive symptoms and schooling was confirmed. Conclusion: no association with cognitive decline was evident due to the relationship of high schooling of participants and control of NCDs

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

Chemical characterization and antioxidant potential of chilean chia seeds and oil (salvia hispanica L.)

The objective of this study was to chemically and nutritionally characterize the commercial chia seeds and oil from Chile and investigate their antioxidant potential by different invitro methods. The chia seed presented a good source of protein (25.32g/100g), oil (30.22g/100g) and total dietary fiber (37.50g/100g), with predominant insoluble fiber (35.07g/100g). The main fatty acids, ranked order of abundance, were α-linolenic acid>linoleic acid>palmitic acid~oleic acid>stearic acid. The triacylglycerols (TAG) in chia oil were identified by direct mass spectrometry using the easy ambient sonic-spray ionization (EASI-MS) technique and linolenic acid (Ln) was present in the most TAG found. The oil also presented a low peroxide index value (2.56mEq peroxide/kg). The samples exhibited a high antioxidant activity by the various invitro methods evaluated; it is due to the presence of phenolic compounds in the seed or oil, which were, mainly, myricetin, quercetin, kaempferol, chlorogenic acid and 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde (3,4-DHPEA-EDA). Our results therefore suggest that Chilean chia seeds and oil should be considered as functional ingredients with high antioxidant potential in food products with commercial applications. © 2014 Elsevier Ltd.The objective of this study was to chemically and nutritionally characterize the commercial chia seeds and oil from Chile and investigate their antioxidant potential by different in vitro methods. 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Sorghum Flour Fractions: Correlations Among Polysaccharides, Phenolic Compounds, Antioxidant Activity And Glycemic Index.

Nutrients composition, phenolic compounds, antioxidant activity and estimated glycemic index (EGI) were evaluated in sorghum bran (SB) and decorticated sorghum flour (DSF), obtained by a rice-polisher, as well as whole sorghum flour (WSF). Correlation between EGI and the studied parameters were determined. SB presented the highest protein, lipid, ash, β-glucan, total and insoluble dietary fiber contents; and the lowest non-resistant and total starch contents. The highest carbohydrate and resistant starch contents were in DSF and WSF, respectively. Phenolic compounds and antioxidant activities were concentrated in SB. The EGI values were: DSF 84.5±0.41; WSF 77.2±0.33; and SB 60.3±0.78. Phenolic compounds, specific flavonoids and antioxidant activities, as well as total, insoluble and soluble dietary fiber and β-glucans of sorghum flour samples were all negatively correlated to EGI. RS content was not correlated to EGI.180116-2